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- Use Monitor
gastrointestinal, pancreatic, liver, and colorectal malignancies
- CA 19-9, a carbohydrate antigen related to Lewis
blood group antigen, has been shown to be elevated in sera of some patients
with gastrointestinal tumors. CA 19-9, as a tumor marker, is helpful
in post-therapeutic monitoring to determine the success of therapy or
the development of recurrence when used serially. CA 19-9 has been reported
as positive in 70% to 80% of pancreatic carcinomas, 50% to 60% of gastric
cancers, 60% of hepatobiliary cancer, 30% of colorectal cancer, and
few lung, breast or prostate cancers. Serum levels may differentiate
pancreatic cancer from pancreatitis. The test may also be positive in
patients with non-neoplastic disease, particularly inflammatory disease
of the bowel, cirrhosis, and autoimmune conditions including rheumatoid
arthritis (33%), systemic lupus erythematosus (32%), and scleroderma
(33%).
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