- American Metabolic Testing Laboratories are using
the modified IRMA method, and Bioluminescent method that tests for
all molecular species of the HCG hormone. Unfortunately, however, there
is NO TEST for the ALPHA subunit of HCG, at this point in time. This
may be the reason for a negative test result in an established cancer
HCG is the pregnancy hormone, and according to Dr.
Schandl, the "malignancy hormone".
Two different, super-sensitive testes
are used, where one will confirm
No other laboratory performs these
tests at the sensitivity level that
we do. Therefore, do-it yourself
pregnancy tests, commercial
lab reports, and the Navarro test
do not accurately report normals
below 5.0mIU/mL. Most cancer patients
have HCG levels between 1
- 5. Our cut-off point is less than
1.0 and the sensitivity of our immunoradiometric
assay (IRMA) is 0.03 mIU/mL!
- Normal levels are <1.0, i.e. less than 1.0 for
the super-sensitive IRMA test, and less than 1.1 for the second Bioluminescent
It is a rather broad-spectrum
tumor marker that can be elevated in
regardless of site. This hormone can be present in men and women
in developing cancers several years proior to diagnosis.
Metabolic Testing Laboratories are using an ultra-sensitive, in-house
modified method for HCG determination. Their technology
radioimmunoassay or RIA. Self-test pregnancy kits, nor regular
clinical laboratory methods can equal the sensitivity
developed by Dr.
- Use Traditionally
the test determines the presence of hCG in patients with gestational
trophoblastic disease; evaluate and monitor male patients with testicular
tumors; follow up molar pregnancy. The quantitative hCG assay should
be used for nonroutine detection of hCG (eg, ectopic pregnancy, threatened
abortions, miscarriages, or very early pregnancy).
- Human chorionic gonadotropin, a glycoprotein hormone,
which is normally produced by the developing placenta, and aberrantly
produced by some germ cell neoplasms, is composed of glycopeptide alpha
and beta subunits. The alpha subunit, a 92 amino acid sequence, is identical
with that of luteinizing hormone, follicle stimulating hormone, and
thyroid-stimulating hormone. The beta subunit, a 145 amino acid sequence,
is unique to hCG and specific tests for it are not subject to hormonal
- Chorionic gonadotropin assays are sometimes used
to support the diagnosis of ectopic pregnancy. Ectopic gestations do
not develop or secrete hCG as do intrauterine pregnancies. Abnormal
hCG levels coupled with transvaginal ultrasound detect many ectopic
pregnancies prior to rupture.
- hCG levels are extremely useful in following those
germ cell neoplasms which produce hCG, particularly trophoblastic neoplasms.
Following evacuation of a trophoblastic lesion, hCG should fall to normal
in 6-8 weeks and stay there. Oral contraceptive use may delay this fall.
Any other delay in the fall, or subsequent rise, is an indication for
other further evaluation.
- In germ cell neoplasms in the male, hCG and alpha
fetoprotein are both useful tumor markers. They can be demonstrated
histochemically in tissue to confirm diagnosis, and can be followed
in serum to evaluate recurrence.
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